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Randomized Controlled Trial
. 2018 Dec;39(4):297-306.
doi: 10.1080/0167482X.2017.1383380. Epub 2017 Oct 10.

PRogram In Support of Moms (PRISM): a pilot group randomized controlled trial of two approaches to improving depression among perinatal women

Nancy Byatt  1 , Tiffany A Moore Simas  1 , Kathleen Biebel  1 , Padma Sankaran  1 , Lori Pbert  1 , Linda Weinreb  1 , Douglas Ziedonis  2 , Jeroan Allison  1
Affiliations
Randomized Controlled Trial

PRogram In Support of Moms (PRISM): a pilot group randomized controlled trial of two approaches to improving depression among perinatal women

Nancy Byatt et al. J Psychosom Obstet Gynaecol. 2018 Dec.

Abstract

Purpose: This pilot study was designed to inform a larger effectiveness trial by: (1) assessing the feasibility of the PRogram In Support of Moms (PRISM) and our study procedures; and, (2) determining the extent to which PRISM as compared to an active comparison group, the Massachusetts Child Access Psychiatry Program (MCPAP) for Moms alone, improves depression among perinatal women.

Methods: Four practices were randomized to either PRISM or MCPAP for Moms alone, a state-wide telephonic perinatal psychiatry program. PRISM includes MCPAP for Moms plus implementation assistance with local champions, training, and implementation of office prompts and procedures to enhance depression screening, assessment and treatment. Patients with Edinburgh Postnatal Depression Scales (EPDS) ≥ 10 were recruited during pregnancy, and completed the EPDS and a structured interview at baseline and 3-12 weeks' postpartum.

Results: Among MCPAP for Moms alone practices, patients' (n = 9) EPDS scores improved from 15.22 to 10.11 (p = 0.010), whereas in PRISM practices patients' (n = 21) EPDS scores improved from 13.57 to 6.19 (p = 0.001); the between groups difference-of-differences was 2.27 (p = 0.341).

Conclusions: PRISM was beneficial for patients, clinicians, and support staff. Both PRISM and MCPAP for Moms alone improve depression symptom severity and the percentage of women with an EPDS >10. The improvement difference between groups was not statistically significant due to limited power associated with small sample size.

Keywords: Maternal depression; mental health; obstetrics; perinatal metal health; post-natal depression.

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Figures

Figure 1
Figure 1
Patient Participant Consort Diagram.
Figure 2
Figure 2
Depression scores by study group and time.
Figure 3
Figure 3
Patients with Edinburgh postnatal depression scales score >10 by study group and time.
See this image and copyright information in PMC

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References

    1. Lindahl V, Pearson JL, Colpe L. Prevalence of suicidality during pregnancy and the postpartum. Arch Womens Ment Health. 2005;8:77–87. - PubMed
    1. Flynn HA, Chermack ST. Prenatal alcohol use: the role of lifetime problems with alcohol, drugs, depression, and violence. J Stud Alcohol Drugs. 2008;69:500–509. - PubMed
    1. Grote NK, Bridge JA, Gavin AR, et al. A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction. Arch Gen Psychiatry. 2010;67:1012–1024. - PMC - PubMed
    1. Britton HL, Gronwaldt V, Britton JR. Maternal postpartum behaviors and mother-infant relationship during the first year of life. J Pediatr. 2001;138:905–909. - PubMed
    1. Forman DR, O’Hara MW, Stuart S, et al. Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship. Dev Psychopathol. 2007;19:585–602. - PubMed

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