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. 1988 Apr 27;149(1-2):141-4.
doi: 10.1016/0014-2999(88)90052-0.

Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker

M Balázs  1 , H Schwarzberg, G Telegdy
Affiliations

Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker

M Balázs et al. Eur J Pharmacol. .

Abstract

The effects of somatostatin on lateral hypothalamic self-stimulation were investigated in rats pretreated with haloperidol, bicuculline, phenoxybenzamine or propranolol. Somatostatin decreased the rate of self-stimulation. Halperidol, bicuculline and phenoxybenzamine potentiated the somatostatin-induced depression of self-stimulation behaviour. Propranolol had no effect. It is suggested that dopaminergic, GABAergic and noradrenergic systems are involved in the somatostatin-induced depression of self-stimulation.

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