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Case Reports
. 1988 Aug 13;2(8607):370-2.
doi: 10.1016/s0140-6736(88)92837-1.

Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone

H L Beynon  1 , N D Garbett, P J Barnes
Affiliations
Case Reports

Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone

H L Beynon et al. Lancet. .

Abstract

Three patients with severe premenstrual exacerbations of asthma are reported. None had responded to conventional treatment, including high-dose corticosteroids. In all cases there was a striking fall premenstrually in peak flow rate. The addition of intramuscular progesterone (100 mg daily in two cases and 600 mg twice a week in one) to the regimen eliminated the premenstrual dips in peak flow, and daily doses of prednisolone were reduced in the three patients.

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