Comparative Study
doi: 10.1126/science.2899909.
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists
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- PMID: 2899909
- DOI: 10.1126/science.2899909
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Comparative Study
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists
Science.
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Abstract
The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.
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