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Comparative Study
. 1988 Aug 5;241(4866):701-3.
doi: 10.1126/science.2899909.

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists

T Honoré  1 , S N Davies, J Drejer, E J Fletcher, P Jacobsen, D Lodge, F E Nielsen
Affiliations
Comparative Study

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists

T Honoré et al. Science. .

Abstract

The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.

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