Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;79(6):666-9.
doi: 10.1111/j.1349-7006.1988.tb02218.x.

Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal

A Martelli  1 , M Ghia, E Mereto, U M Marinari, G Brambilla
Affiliations

Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal

A Martelli et al. Jpn J Cancer Res. 1988 Jun.

Abstract

The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. ) Kasai , H. , Kumeno , K. , Yamaizumi , Z. , Nishimura , S. , Nagao , M. , Fujita , Y. , Sugimura , T. , Nukaya , H. and Kosuge , T.Mutagenicity of methylglyoxal in coffee . Gann , 73 , 681 – 683 ( 1982. ). - PubMed
    1. ) Brambilla , G. , Sciabα , L. , Faggin , P. , Finollo , R. , Bassi , A. M. , Ferro , M. and Marinari , U. M.Methylglyoxal‐induced DNA‐protein cross‐links and cytotoxicity in Chinese hamster ovary cells . Carcinogenesis , 6 , 683 – 686 ( 1985. ). - PubMed
    1. ) Cajelli , E. , Canonero , R. , Martelli , A. and Brambilla , G.Methylglyoxal‐induced mutation to 6‐thioguanine resistance in V79 cells . Mutat. Res. , 190 , 47 – 50 ( 1987. ). - PubMed
    1. ) Faggin , P. , Bassi , A. M. , Finollo , R. and Brambilla , G.Induction of sister‐chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal . Mutat. Res. , 144 , 189 – 191 ( 1985. ). - PubMed
    1. ) Furihata , C. , Sato , Y. , Matsushima , T. and Tatematsu , M.Induction of ornithine decarboxylase and DNA synthesis in rat stomach mucosa by methylglyoxal . Carcinogenesis , 6 , 91 – 94 ( 1985. ). - PubMed

Publication types

MeSH terms

LinkOut - more resources