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. 1988 Jun;79(6):666-9.
doi: 10.1111/j.1349-7006.1988.tb02218.x.

Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal

A Martelli  1 , M Ghia, E Mereto, U M Marinari, G Brambilla
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Induction and promotion of gamma-glutamyltranspeptidase-positive foci in the rat liver by methylglyoxal

A Martelli et al. Jpn J Cancer Res. 1988 Jun.

Abstract

The effect of pre-(initiation) and post-(promotion) administration of methylglyoxal (MG) on the induction of gamma-glutamyltranspeptidase (GGT)-positive foci in the liver of F344 male rats was investigated. GGT-positive foci were produced in dose-related amounts by 0.05 and 0.2% MG in drinking water, either when administered to uninitiated rats or when given in the promotion phase.

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