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. 1988 Sep 17;2(8612):644-7.
doi: 10.1016/s0140-6736(88)90467-9.

Xenobiotic metabolism in motor neuron disease

G Steventon  1 , A C Williams, R H Waring, H S Pall, D Adams
Affiliations

Xenobiotic metabolism in motor neuron disease

G Steventon et al. Lancet. .

Abstract

Debrisoquine, carbocysteine, and paracetamol were selected as safe drugs to investigate the ability of the liver's microsomal system to oxidise carbon, oxidise sulphur, and conjugate sulphate in patients with motor neuron disease (MND), other hospital patients, and healthy volunteers. Subjects with poor sulphur-oxidising and sulphur-conjugating activities were heavily over-represented in the MND group.

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