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. 1988 Sep 24;2(8613):714-7.
doi: 10.1016/s0140-6736(88)90188-2.

Treatment of anismus in intractable constipation with botulinum A toxin

R I Hallan  1 , N S Williams, J Melling, D J Waldron, N R Womack, J F Morrison
Affiliations

Treatment of anismus in intractable constipation with botulinum A toxin

R I Hallan et al. Lancet. .

Abstract

In seven patients with anismus the striated sphincter muscle complex was selectively weakened by local injection of Clostridium botulinum type A toxin. Symptom scores improved significantly and correlated with a significant reduction in the maximum voluntary and canal squeeze pressure and a significant increase in the anorectal angle on straining. Botulinum A toxin seems to be promising treatment for some patients with anismus.

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