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Case Reports
. 2017 Sep 15;7(9):e607.
doi: 10.1038/bcj.2017.89.

Blinatumomab-induced lineage switch of B-ALL with t(4:11)(q21;q23) KMT2A/AFF1 into an aggressive AML: pre- and post-switch phenotypic, cytogenetic and molecular analysis

C L Haddox  1 , A A Mangaonkar  2 , D Chen  3 , M Shi  3 , R He  3 , J L Oliveira  3 , M R Litzow  2 , A Al-Kali  2 , W J Hogan  2 , M A Elliott  2
Affiliations
Case Reports

Blinatumomab-induced lineage switch of B-ALL with t(4:11)(q21;q23) KMT2A/AFF1 into an aggressive AML: pre- and post-switch phenotypic, cytogenetic and molecular analysis

C L Haddox et al. Blood Cancer J. .
No abstract available

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Conflict of interest statement

Dr Mark Litzow receives research support for clinical trials from Amgen. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distinct morphologic and immunophenotypic features of B-ALL blasts and AML blasts following lineage switch. (a) The lymphoblasts of B-ALL had scant cytoplasm, round nuclei, fine chromatin and inconspicuous nucleoli. (b) The myeloid blasts of AML had abundant cytoplasm, folded nuclei, fine chromatin and occasional prominent nucleoli. (c and d) Bone marrow biopsy revealed packed B-lymphoblasts with scant cytoplasm and myeloid blasts with more abundant cytoplasm, respectively. (e, g, and i) show that the lymphoblasts expressed dim CD45, lower side scatter, CD19, CD34 (partial), and terminal deoxynucleotidyl transferase (TdT). They were negative for myeloperoxidase (MPO). (f, h and j) show that the myeloid blasts expressed bright CD45, high side scatter and MPO, but are negative for CD19, CD34 and TdT.
See this image and copyright information in PMC

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