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. 2017 Oct 10;12(10):e0185404.
doi: 10.1371/journal.pone.0185404. eCollection 2017.

Radial artery neointimal hyperplasia after transradial PCI-Serial optical coherence tomography volumetric study

Petr Kala  1 , Jan Kanovsky  1 , Tereza Novakova  1 , Roman Miklik  1 , Otakar Bocek  1 , Martin Poloczek  1 , Petr Jerabek  1 , Lenka Prymkova  1 , Tomas Ondrus  1 , Jiri Jarkovsky  2 , Milan Blaha  2 , Gary S Mintz  3
Affiliations

Radial artery neointimal hyperplasia after transradial PCI-Serial optical coherence tomography volumetric study

Petr Kala et al. PLoS One. .

Abstract

Aims: Transradial catheterization (TRC) is a dominant access site for coronary catheterization and percutaneous coronary interventions (PCI) in many centers. Previous studies reported higher intimal thickness of the radial artery (RA) wall in patients with a previous history of TRC. In this investigation the aim was to assess the intimal changes of RA using the optical coherence tomography (OCT) intravascular imaging in a serial manner.

Methods and results: 100 patients with the diagnosis of non-ST-elevation myocardial infarction (nSTEMI) treated by PCI were enrolled (6 patients were excluded from this analysis because of occluded RA at follow-up [2 patients] and insufficient quality of OCT images [4 patients]). An 54mm long OCT run of the RA was performed immediately after the index PCI and repeated 9 months later. Volumetric analyses of the intimal layer and lumen changes were conducted. Median intimal volume at baseline versus 9 months was 33.9mm3 (19.0; 69.4) versus 39.0mm3 (21.7; 72.6) (p<0.001); and median arterial lumen volume was 356.3mm3 (227.8; 645.3) versus 304.7mm3 (186.1; 582.7) (p<0.001). There was no significant difference in the effect of any clinical factor on the RA volume changes.

Conclusions: OCT volumetric analyses at baseline and 9 months showed a significant increase in the radial artery intimal layer volume and a decrease in lumen volume after transradial PCI. No significant factors affecting this process were identified.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Optical coherence tomography of RA—procedure scheme.
Legend: A-Sheath tip position during the OCT procedure, B-Original sheath tip position during the PCI, C-Start position of the OCT probe.
Fig 2
Fig 2. Representative OCT cross-section frame of the radial artery and its analysis.
Legend: A-intimal layer, B-media, C-adventitia.
Fig 3
Fig 3. Distributions of RA intimal layer volume in baseline and follow-up measurements.
Fig 4
Fig 4. Distributions of RA luminal volume in baseline and follow-up measurements.
Fig 5
Fig 5. Change in the volume of intima layer of the arterial wall in individual patients (mm3).
Fig 6
Fig 6. Change in the volume of arterial lumen in individual patients (mm3).
See this image and copyright information in PMC

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