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Multicenter Study
. 2017 Oct 10;12(10):e0186143.
doi: 10.1371/journal.pone.0186143. eCollection 2017.

Major depressive disorder and suicide risk among adult outpatients at several general hospitals in a Chinese Han population

Haiyan Li  1   2   3 , Xinni Luo  2 , Xiaoyin Ke  2 , Qing Dai  2 , Wei Zheng  2 , Chanjuan Zhang  2 , Ryan M Cassidy  4 , Jair C Soares  4 , XiangYang Zhang  4 , Yuping Ning  1   2   3
Affiliations
Multicenter Study

Major depressive disorder and suicide risk among adult outpatients at several general hospitals in a Chinese Han population

Haiyan Li et al. PLoS One. .

Abstract

Background: Somatic complaints are often the presenting symptoms of major depressive disorder (MDD) in the outpatient context, because this may go unrecognized. It is well understood that MDD carries an increased risk of suicide. This study aimed to identify the risk factors and association with both MDD and suicidality among Han Chinese outpatients.

Methods: A multicenter study was carried out in 5189 outpatient adults (≥18 years old) in four general hospitals in Guangzhou, China. The 1392 patients who had the Patient Health Questionnaire-9 (PHQ-9) score ≥ 5, indicating depressive symptoms were offered an interview with a psychiatrist by the Mini International Neuropsychiatric Interview (MINI); 819 patients consented and completed the MINI interview. MINI module B was used to assess suicidality. Stepwise binary logistic models were used to estimate the relationship between a significant risk factor and suicide or MDD. According to with or without MDD, the secondary analysis was performed using the logistic regression model for the risk of suicidility.

Results: The current prevalence of MDD and the one month prevalence of suicidality were 3.7% and 2.3% respectively. The odds ratio of suicidality in women was more than twice that in men (OR = 2.62; 95% CI 1.45-4.76). Other risk factors which were significantly associated with suicidality were: living alone, higher education, self-reported depression, getting psychiatric diagnoses (MDD, anxiety disorders, and bipolar disorders). Significant risk factors for MDD were also noticed, such as comorbid anxiety disorders, self-reported anxiety, insomnia, suicidal ideation.

Limitation: It's a cross-sectional study in outpatient clinics using self-report questionnaires.

Conclusion: This study provides valuable data about the risk factors and association of MDD and suicide risk in adult outpatients in Han Chinese. Those factors allow better the employment of preventative measures.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of the study on prevalence of major depressive disorders and suicide risk from general hospitals in Guangzhou.
Fig 2
Fig 2. The proportion of suicidal ideation, plan and attempt in all subjects and MDD.
See this image and copyright information in PMC

References

    1. World Health Organization (WHO) WOoNC. (2016) Available at:http://wwwwhoint/mediacentre/factsheets/fs369/en/.
    1. Kessler RC, Bromet EJ. (2013) The epidemiology of depression across cultures. Annu Rev Public Health 34: 119–138. https://doi.org/.10.1146/annurev-publhealth-031912-114409 . - PMC - PubMed
    1. Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382: 1575–1586. doi: 10.1016/S0140-6736(13)61611-6 . - DOI - PubMed
    1. Nock MK, Borges G, Bromet EJ, Cha CB, Kessler RC, Lee S. (2008) Suicide and suicidal behavior. Epidemiol Rev 30: 133–154. https://doi.org/.10.1093/epirev/mxn002 . - PMC - PubMed
    1. (WHO) WHO. (2014) Preventing Suicide:a Global Imperative. Available at: http://wwwwhoint/mental_health/suicide-prevention/en/.

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