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. 1988 Jun;27(6):653-6.
doi: 10.1016/0028-3908(88)90189-x.

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

W Danysz  1 , J T Wroblewski, E Costa
Affiliations

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

W Danysz et al. Neuropharmacology. 1988 Jun.

Abstract

2-Amino-5-phosphonovalerate (APV, icv) phencyclidine (PCP, ip) and scopolamine (sc) dose-dependently disrupted short term working memory in radial maze. These drugs injected before, but not after training attenuated retention of long term memory in passive avoidance task. A relation of PCP action to its antagonism at NMDA receptors may be suggested.

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