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Review
. 2017 Oct 9;43(1):6-9.
doi: 10.1016/j.devcel.2017.09.020.

Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR

Ben Ewen-Campen  1 , Stephanie E Mohr  2 , Yanhui Hu  2 , Norbert Perrimon  3
Affiliations
Free article
Review

Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR

Ben Ewen-Campen et al. Dev Cell. .
Free article

Abstract

Single-gene knockout experiments can fail to reveal function in the context of redundancy, which is frequently observed among duplicated genes (paralogs) with overlapping functions. We discuss the complexity associated with studying paralogs and outline how recent advances in CRISPR will help address the "phenotype gap" and impact biomedical research.

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