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Comment
. 2017 Oct 9;32(4):399-401.
doi: 10.1016/j.ccell.2017.09.011.

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy

W Nathaniel Brennen  1 , John T Isaacs  2
Affiliations
Free article
Comment

Cellular Origin of Androgen Receptor Pathway-Independent Prostate Cancer and Implications for Therapy

W Nathaniel Brennen et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Bluemn et al. report that ∼20% of metastatic castration-resistant prostate cancers express neither AR nor neuroendocrine genes and show AR pathway-independent growth, driven instead by a FGFR/MAPK/ID1 signaling cascade. These results provide a strong rationale for co-targeting AR bypass pathways with initial AR antagonism.

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  • Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.
    Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS. Bluemn EG, et al. Cancer Cell. 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003. Cancer Cell. 2017. PMID: 29017058 Free PMC article.

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