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. 2017 Nov 1;27(21):4786-4788.
doi: 10.1016/j.bmcl.2017.09.064. Epub 2017 Sep 30.

Carborane-linked 2'-deoxyuridine 5'-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA

Jana Balintová  1 , Anna Simonova  1 , Magdalena Białek-Pietras  2 , Agnieszka Olejniczak  2 , Zbigniew J Lesnikowski  3 , Michal Hocek  4
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Carborane-linked 2'-deoxyuridine 5'-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA

Jana Balintová et al. Bioorg Med Chem Lett. .

Abstract

5-[(p-Carborane-2-yl)ethynyl]-2'-deoxyuridine 5'-O-triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases.

Keywords: Carboranes; DNA polymerase; Nucleoside triphosphates; Nucleotides; Oligonucleotides.

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