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. 2017 Oct 10;7(10):e017835.
doi: 10.1136/bmjopen-2017-017835.

Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016: a hospital-based test-negative case - control study in Lithuania

Monika Kuliese  1 , Ligita Jancoriene  2   3 , Rita Grimalauskaite  4 , Birute Zablockiene  2   3 , Gyte Damuleviciene  4 , Daiva Velyvyte  1 , Vita Lesauskaite  4 , Arvydas Ambrozaitis  2   3 , Aukse Mickiene  1 , Giedre Gefenaite  1
Affiliations

Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015-2016: a hospital-based test-negative case - control study in Lithuania

Monika Kuliese et al. BMJ Open. .

Abstract

Objective: A case-control study was conducted to assess seasonal influenza vaccine effectiveness (SIVE) during the 2015-2016 influenza season.

Methods: A study was performed in three departments in Lithuania between 1 December 2015 and 1 May 2016. Data on demographic and clinical characteristics including influenza vaccination status were collected from the patients recommended to receive the seasonal influenza vaccine. Influenza virus infection was confirmed by multiplex reverse transcription polymerase chain reaction (RT-PCR) .

Results: Ninety-one (56.4%) of the 163 included subjects were ≥65 years old. Fifteen (9.2%) subjects were vaccinated against influenza at least 2 weeks before the onset of influenza symptoms, 12 of them were ≥65 years old. Of the 72 (44.2%) influenza virus positive cases, 65 (39.9%) were confirmed with influenza A (including 50 cases of influenza A(H1N1)pdm09), eight (4.9%) were confirmed with influenza B and one was a co-infection. Unadjusted SIVE against any influenza, influenza type A and influenza A(H1N1)pdm09 was 57% (95% CI -41% to 87%), 52% (95% CI -57% to 85%) and 70% (95% CI -43% to 94%) respectively.

Conclusion: Although SIVE estimates were not statistically significant the point estimates suggest moderate effectiveness against influenza type A.

Keywords: effectiveness; influenza; influenza vaccination; lithuania; test-negative case-control study.

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Figures

Figure 1
Figure 1
Number of specimens for influenza (sub)type during 2015–2016 influenza season in the study.
Figure 2
Figure 2
Number of specimens positive for influenza (sub)type in Lithuania during 2015–2016 influenza season.
See this image and copyright information in PMC

References

    1. Commission of the European Communities. Council recommendation of 13 July 2009 on Seasonal Influenza vaccination. Off J 2009;09:1–12. L 353, 13/7/.
    1. Rondy M, Puig-Barbera J, Launay O, et al. . 2011-12 Seasonal Influenza Vaccines Effectiveness against Confirmed A(H3N2) Influenza Hospitalisation: pooled Analysis from a European Network of Hospitals. A pilot study.. PLoS One 2013:8. - PMC - PubMed
    1. Thompson WW, et al. . Influenza-Associated Hospitalizations in the United States. JAMA 2004;292:1333–40. 10.1001/jama.292.11.1333 - DOI - PubMed
    1. Barnes M, Heywood AE, Mahimbo A, et al. . Acute myocardial infarction and influenza: a meta-analysis of case–control studies. Heart 2015;101:1738–47. 10.1136/heartjnl-2015-307691 - DOI - PMC - PubMed
    1. Plans-Rubió P. Prevention and control of influenza in persons with chronic obstructive pulmonary disease. International Journal of COPD 2007;2:41–53. 10.2147/copd.2007.2.1.41 - DOI - PMC - PubMed

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