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Review
. 2017 Sep 26:8:664.
doi: 10.3389/fphar.2017.00664. eCollection 2017.

Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders

Chun-Tao Yang  1   2 , Li Chen  1 , Shi Xu  2 , Jacob J Day  2 , Xiang Li  1 , Ming Xian  2
Affiliations
Review

Recent Development of Hydrogen Sulfide Releasing/Stimulating Reagents and Their Potential Applications in Cancer and Glycometabolic Disorders

Chun-Tao Yang et al. Front Pharmacol. .

Abstract

As an important endogenous gaseous signaling molecule, hydrogen sulfide (H2S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H2S, especially decreased. Therefore, the supplement of H2S is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the in vivo levels of H2S by administration of gaseous H2S, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable H2S donors or materials, and using H2S stimulating agents. In this article, we reviewed the recent development of H2S releasing/stimulating reagents and their potential applications in two common pathological processes including cancer and glycometabolic disorders.

Keywords: cancer; donor; glucose metabolism; hydrogen sulfide.

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Figures

FIGURE 1
FIGURE 1
The structures of representative synthetic H2S donors.
FIGURE 2
FIGURE 2
The chemical structure of TTM.
FIGURE 3
FIGURE 3
H2O2-mediated COS/H2S release from Peroxy TCM donors.
FIGURE 4
FIGURE 4
H2S release from esterase-activated donors.
FIGURE 5
FIGURE 5
Esterase-activated COS/H2S release.
FIGURE 6
FIGURE 6
Nitroreductase-activated H2S donors.
FIGURE 7
FIGURE 7
(A) SATO based polymers. (B) SATO based micelles.
FIGURE 8
FIGURE 8
The structures of polyNTA and PEG-ADT.
FIGURE 9
FIGURE 9
SG-1002 Components.
FIGURE 10
FIGURE 10
The Structures of SAC and SPRC and their H2S release reaction.
FIGURE 11
FIGURE 11
Effects of H2S on insulin secretion by beta cells. (A) Insulin secretion is stimulated at high glucose levels and (B) inhibited at high H2S or low glucose levels. GLUT2, glucose transporter type 2; G, glucose; G-6-P, glucose 6-phosphate; MITO, mitochondria; ○, targets of H2S; ⊕, to activate; Θ, to inhibit.
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