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Review
. 2017 Oct;21(4):390-398.
doi: 10.1055/s-0036-1597665. Epub 2017 Jan 4.

HMGB1 in the Pathogenesis of Nasal Inflammatory Diseases and its Inhibition as New Therapeutic Approach: A Review from the Literature

Luisa Maria Bellussi  1 , Serena Cocca  1 , Giulio Cesare Passali  2 , Desideri Passali  1
Affiliations
Review

HMGB1 in the Pathogenesis of Nasal Inflammatory Diseases and its Inhibition as New Therapeutic Approach: A Review from the Literature

Luisa Maria Bellussi et al. Int Arch Otorhinolaryngol. 2017 Oct.

Abstract

Introduction This study is a systematic review on recent developments about the importance of HMGB1 protein in the pathogenesis of rhino-sinusal inflammatory diseases. We also report data on the use of 18-β-glycyrrhetic acid (GA), which has been shown able to inhibit the pro-inflammatory activities of HMGB1, in young patients affected by allergic rhinitis and complaining of nasal obstruction as main symptom. Objectives The objective of this study was to review the literature to demonstrate the importance of HMGB1 in the pathogenesis of nasal inflammatory disorders and understand whether the inhibition of this protein may be an efficacious and innovative therapeutic strategy for patients with rhino-sinusal inflammation. Data Synthesis Authors searched for pertinent articles indexed in PubMed, Scopus, and other health journals between 2004 and 2015. In total, the authors gathered 258 articles: 219 articles through Pubmed and 39 articles from other search engines. The search terms used were as follows: HMGB1 AND "respiratory epithelium," "airway inflammation," "rhinitis," "allergic rhinitis," "rhinosinusitis," "nasal polyposis," "glycyrrhetic acid," "children." Conclusions Patients with severe symptoms have the highest serum levels and the highest extracellular expression of HMGB1. GA inhibits HMGB1 chemotactic and mitogenic function by a scavenger mechanism on extracellular HMGB1 accumulation stimulated by lipopolysaccharides in vitro. Treatment of allergic rhinitis with GA is not associated with local or systemic side effects in children and adults.

Keywords: HMGB1; allergic rhinitis; chronic rhinosinusitis; glycyrrhetic acid; rhino-sinusal inflammation.

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Conflict of interest statement

Conflict of Interest and Financial Disclosure The authors declare that there is no conflict of interest and that no financial support or interest is vested in this study.

Figures

Fig. 1
Fig. 1
Flow chart of steps in systematic review.
See this image and copyright information in PMC

References

    1. Turner P J, Kemp A S. Allergic rhinitis in children. J Paediatr Child Health. 2012;48(04):302–310. - PubMed
    1. Kemp A S. Allergic rhinitis. Paediatr Respir Rev. 2009;10(02):63–68. - PubMed
    1. Konstantinopoulou S, Sideris G A, DelRosso L M. The Role of Co-Morbidities. Curr Probl Pediatr Adolesc Health Care. 2016;46(01):7–10. - PubMed
    1. Gentile D, Bartholow A, Valovirta E, Scadding G, Skoner D.Current and future directions in pediatric allergic rhinitis J Allergy Clin Immunol Pract 2013103214–226., quiz 227 - PubMed
    1. Brozek J L, Bousquet J, Baena-Cagnani C E et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126(03):466–476. - PubMed