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. 2017 Sep 26;3(2):e000495.
doi: 10.1136/rmdopen-2017-000495. eCollection 2017.

Health-related quality of life and depression among participants in the Sjögren's International Collaborative Clinical Alliance registry

Annie Chou  1 , John A Gonzales  2 , Troy E Daniels  1 , Lindsey A Criswell  3 , Stephen C Shiboski  4 , Caroline H Shiboski  1
Affiliations

Health-related quality of life and depression among participants in the Sjögren's International Collaborative Clinical Alliance registry

Annie Chou et al. RMD Open. .

Abstract

Objective: To examine health-related quality of life (HRQoL) and depression among participants in an international Sjögren's syndrome (SS) registry, comparing those with and without SS.

Methods: Cross-sectional study of participants in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. The 2016 American College of Rheumatology/European League Against Rheumatism SS classification criteria were used to determine disease status. HRQoL was assessed using the Short Form 12, version 2 Health Survey to derive scores for physical component summary (PCS) and mental component summary (MCS). Depression was assessed using the 9-Item Patient Health Questionnaire. Multivariate linear and logistic regression analyses were performed to identify predictors of HRQoL and depression while controlling for potential confounders.

Results: Among 2401 SICCA participants who had symptoms of dry eyes and dry mouth, 1051 had SS (44%) and 1350 did not (56%). After controlling for confounders, when compared with non-SS participants, those with SS had better PCS (p<0.001, β=2.43, 95% CI 1.57 to 3.29), MCS (p=0.002, β=1.37, 95% CI 0.50 to 2.23) and lower adjusted odds of depression (p<0.001, OR 0.67, 95% CI 0.55 to 0.81). Other significant predictors of HRQoL and depression included employment, country of residence and use of medication with anticholinergic effect or for management of SS-related signs and symptoms.

Conclusion: Our results suggest that among symptomatic patients, having a diagnosis of SS may be associated with better emotional and psychological well-being compared with patients without a diagnosis. Having a definitive diagnosis of SS may encourage patients to obtain a better understanding of their disease and have coping mechanisms in place to better manage their symptoms.

Keywords: health services research; multidisciplinary team-care; sjøgren’s syndrome.

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Conflict of interest statement

Competing interests: None declared.

References

    1. Malladi AS, Sack KE, Shiboski SC, et al. . Primary Sjögren. Arthritis Care Res 2012;64:911–8. - PMC - PubMed
    1. Patel R, Shahane A. The epidemiology of Sjögren. Clin Epidemiol 2014;6:247–55. - PMC - PubMed
    1. Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med 2004;164:1275–84. 10.1001/archinte.164.12.1275 - DOI - PubMed
    1. Ergun S, Cekici A, Topcuoglu N, et al. . Oral status and Candida colonization in patients with Sjögren’s Syndrome. Med Oral Patol Oral Cir Bucal 2010;15:e310–e315. - PubMed
    1. Kruszka P, O’Brian RJ. Diagnosis and management of Sjögren syndrome. Am Fam Physician 2009;79:465–70. - PubMed

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