Role of microbiota on lung homeostasis and diseases

Jian Wang^{1

2}, Fengqi Li³, Zhigang Tian^{4

5}

Affiliations

¹ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China. ustcwj@mail.ustc.edu.cn.
² Neuroimmunology and MS Research, Neurology Clinic, University Hospital Zurich, University Zurich, Zurich, 8091, Switzerland. ustcwj@mail.ustc.edu.cn.
³ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China.
⁴ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China. tzg@ustc.edu.cn.
⁵ Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. tzg@ustc.edu.cn.

PMID: 29019144
PMCID: PMC7089139
DOI: 10.1007/s11427-017-9151-1

Review

Role of microbiota on lung homeostasis and diseases

Jian Wang et al. Sci China Life Sci. 2017 Dec.

. 2017 Dec;60(12):1407-1415.

doi: 10.1007/s11427-017-9151-1. Epub 2017 Oct 9.

Authors

Jian Wang^{1

2}, Fengqi Li³, Zhigang Tian^{4

5}

Affiliations

¹ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China. ustcwj@mail.ustc.edu.cn.
² Neuroimmunology and MS Research, Neurology Clinic, University Hospital Zurich, University Zurich, Zurich, 8091, Switzerland. ustcwj@mail.ustc.edu.cn.
³ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China.
⁴ Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China. tzg@ustc.edu.cn.
⁵ Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China. tzg@ustc.edu.cn.

PMID: 29019144
PMCID: PMC7089139
DOI: 10.1007/s11427-017-9151-1

Abstract

The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16S rRNA sequencing, has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.

Keywords: homeostasis; lung; lung disease; microbiota.

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Role of microbiota on lung homeostasis and diseases

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Role of microbiota on lung homeostasis and diseases

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