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Review
. 2017 Oct;32(5):369-375.
doi: 10.1007/s12250-017-4027-2. Epub 2017 Oct 10.

Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis

Lu Dai  1   2   3 , Zhen Lin  4 , Wei Jiang  5 , Erik K Flemington  4 , Zhiqiang Qin  6   7   8
Affiliations
Review

Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis

Lu Dai et al. Virol Sin. 2017 Oct.

Abstract

Lipids are essential for mammalian cells to maintain many physiological functions. Emerging evidence has shown that cancer cells can develop specific alterations in lipid biosynthesis and metabolism to facilitate their survival and various malignant behaviors. To date, the precise role of cellular lipids and lipid metabolism in viral oncogenesis is still largely unclear with only a handful of literature covering this topic to implicate lipid metabolism in oncogenic virus associated pathogenesis. In this review, we focus on the role of lipid biosynthesis and metabolism in the pathogenesis of the Kaposi's sarcoma-associated herpesvirus, a common causative factor for cancers arising in the immunocompromised settings.

Keywords: Kaposi’s sarcoma-associated herpesvirus (KSHV); herpesvirus; lipid metabolism.

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References

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