Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jun;7(6):1675-82.
doi: 10.1002/j.1460-2075.1988.tb02995.x.

The structure of the human CD2 gene and its expression in transgenic mice

G Lang  1 , D Wotton, M J Owen, W A Sewell, M H Brown, D Y Mason, M J Crumpton, D Kioussis
Affiliations

The structure of the human CD2 gene and its expression in transgenic mice

G Lang et al. EMBO J. 1988 Jun.

Abstract

We report the genomic organization of the human CD2 gene and its expression in transgenic mice. A 28.5 kb segment of DNA consisting of 4.5 kb 5' flanking sequences, 15 kb containing the gene's five exons and 9 kb of 3' flanking sequences can direct the expression of the CD2 gene only on thymocytes, circulating T cells and megakaryocytes of the transgenic mice. The expression of each copy of the human CD2 transgene appears to be as high as the endogenous mouse CD2 gene and as high as the expression on the surface of human T lymphocytes, independent of the site of integration and dependent on the copy number of genes that have integrated.

PubMed Disclaimer

References

    1. J Mol Biol. 1970 Oct 14;53(1):159-62 - PubMed
    1. Br J Haematol. 1985 Mar;59(3):395-409 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Cell. 1979 Apr;16(4):777-85 - PubMed

MeSH terms