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Review
. 2017 Oct 19;550(7676):345-353.
doi: 10.1038/nature24286. Epub 2017 Oct 11.

DNA sequencing at 40: past, present and future

Jay Shendure  1   2 , Shankar Balasubramanian  3   4 , George M Church  5 , Walter Gilbert  6 , Jane Rogers  7 , Jeffery A Schloss  8 , Robert H Waterston  1
Affiliations
Review

DNA sequencing at 40: past, present and future

Jay Shendure et al. Nature. .

Erratum in

Abstract

This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.

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References

    1. Annu Rev Biochem. 1988;57:1-28 - PubMed
    1. PLoS Biol. 2007 Sep 4;5(10):e254 - PubMed
    1. Science. 2014 Mar 21;343(6177):1360-3 - PubMed
    1. Nat Nanotechnol. 2015 Jan;10(1):76-83 - PubMed
    1. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5932-7 - PubMed