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. 1988 Oct;80(2):177-80.
doi: 10.1007/BF00702863.

Genetic mapping of anhidrotic ectodermal dysplasia: DXS159, a closely linked proximal marker

A Hanauer  1 , Y Alembik, B Arveiler, L Formiga, S Gilgenkrantz, J L Mandel
Affiliations

Genetic mapping of anhidrotic ectodermal dysplasia: DXS159, a closely linked proximal marker

A Hanauer et al. Hum Genet. 1988 Oct.

Abstract

Three families with anhidrotic ectodermal dysplasia (AED) have been studied by linkage analysis with seven polymorphic DNA markers from the Xp11-q21 region. Previously reported linkage to DXYS1 (Xq13-q21) has been confirmed (z (theta) = 4.08 at theta = 0.05) and we have also established linkage to another polymorphic locus, DXS159, located in Xq11-q12 (z (theta) = 4.28 at theta = 0.05). Physical mapping places DSX159 proximal to the Xq12 breakpoint of an X autosome translocation found in a female with clinical signs of ectodermal dysplasia. Of all markers that have been used in linkage analysis of AED, DXS159 would appear the closest on the proximal side of the disease locus.

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References

    1. Cytogenet Cell Genet. 1974;13(1):29-34 - PubMed
    1. Somatic Cell Genet. 1976 Sep;2(5):401-10 - PubMed
    1. Cytogenet Cell Genet. 1987;46(1-4):277-315 - PubMed
    1. Hum Genet. 1987 Apr;75(4):378-80 - PubMed
    1. J Med Genet. 1966 Sep;3(3):169-76 - PubMed

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