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. 2017 Oct 16;65(9):1577-1579.
doi: 10.1093/cid/cix569.

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R Celestin  1 , Stephen R Odom  1 , Konstantia Angelidou  2 , Scott R Evans  2 , Raul Coimbra  3 , Christopher A Guidry  4 , Joseph Cuschieri  5 , Kaysie L Banton  6 , Patrick J O'Neill  7 , Reza Askari  8 , Nicholas Namias  9 , Therèse M Duane  10 , Jeffrey A Claridge  11 , E Patchen Dellinger  5 , Robert A Sawyer  12 , Charles H Cook  1
Affiliations

Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections

Arthur R Celestin et al. Clin Infect Dis. .

Abstract

Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antimicrobial therapy for intra-abdominal infection (STOP-IT), and results suggest global superiority of short-duration therapy for intra-abdominal infections.

Keywords: antibiotic resistance; desirability of outcome ranking; duration of antibiotic therapy; intra-abdominal infection; surgical infection.

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Figures

Figure 1.
Figure 1.
Overview of suggested trial design and analysis in clinical trials using DOOR/RADAR. Abbreviations: DOOR/RADAR, desirability of outcome ranking/response adjusted for duration of antibiotic risk; PNA, pneumonia; STOP-IT, Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection; UTI, urinary tract infection.
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References

    1. Luyt CE, Bréchot N, Trouillet JL, Chastre J. Antibiotic stewardship in the intensive care unit. Crit Care 2014; 18:480. - PMC - PubMed
    1. Peron EP, Hirsch AA, Jury LA, Jump RL, Donskey CJ. Another setting for stewardship: high rate of unnecessary antimicrobial use in a Veterans Affairs long-term care facility. J Am Geriatr Soc 2013; 61:289–90. - PMC - PubMed
    1. Rice LB. The clinical consequences of antimicrobial resistance. Curr Opin Microbiol 2009; 12:476–81. - PubMed
    1. Gould IM. Coping with antibiotic resistance: the impending crisis. Int J Antimicrob Agents 2010; 36(suppl 3):S1–2. - PubMed
    1. Bignardi GE. Risk factors for Clostridium difficile infection. J Hosp Infect 1998; 40:1–15. - PubMed

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