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. 2017 Dec;89(4):324-327.
doi: 10.1016/j.diagmicrobio.2017.08.017. Epub 2017 Aug 25.

Genomic characterization of an extensively drug-resistant KPC-2-producing Klebsiella pneumoniae ST855 (CC258) only susceptible to ceftazidime-avibactam isolated in Brazil

Caio Augusto Martins Aires  1 , Michael J Rybak  2 , Juwon Yim  2 , Polyana Silva Pereira  1 , Cláudio M Rocha-de-Souza  1 , Rodolpho Mattos Albano  3 , Valdelucia Oliveira Cavalcanti  4 , Ana Paula D'Alincourt Carvalho-Assef  1 , Marisa Zenaide Ribeiro Gomes  1 , Marise Dutra Asensi  5
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Genomic characterization of an extensively drug-resistant KPC-2-producing Klebsiella pneumoniae ST855 (CC258) only susceptible to ceftazidime-avibactam isolated in Brazil

Caio Augusto Martins Aires et al. Diagn Microbiol Infect Dis. 2017 Dec.
Free article

Abstract

In this study, we describe the genetic features of an XDR KPC-2-producing Klebsiella pneumoniae isolate by using whole-genome sequencing, its clinical-epidemiological context and susceptibility against antimicrobial combinations. The isolate belongs to clonal complex 258 and harbors several acquired genes and mutations associated with antimicrobial resistance.

Keywords: Colistin resistance; Extensively drug-resistant; KPC-2; Klebsiella pneumoniae; XDR.

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