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. 2017 Sep 27:5:72.
doi: 10.3389/fchem.2017.00072. eCollection 2017.

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs

Simona Sestito  1 , Giulia Nesi  1 , Rongbiao Pi  2   3   4 , Marco Macchia  1 , Simona Rapposelli  1
Affiliations

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs

Simona Sestito et al. Front Chem. .

Abstract

H2S is a gaseous molecule able to trigger a plethora of central physiological and pharmacological effects as antioxidant, pro- and anti-inflammatory, pro- and anti-nociceptive, neuromodulator, and cytoprotective. The polypharmacology of H2S depends on the wide variety of targets implicated, but, despite the efforts, the mechanisms of action that should clarify its activity are still not completely unrevealed. Nevertheless, many attempts to exploit the multifaceted profile of this molecule have already been accomplished and many chemical entities containing an H2S-releasing pharmacophore have been synthetized. Here we discuss recent investigations on multitarget molecules able to release H2S, with a particular focus on the combinations of "native drug" with moieties structurally able to release H2S and their applications as therapeutic tools in bone disease, gastrointestinal system and neurodegenerative disorders.

Keywords: H2S-donors; antioxidants; bone disease; hybrid molecules; hydrogen sulfide; multifunctional compounds; multitarget-directed ligands; neurodegenerative disorders.

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Figures

Figure 1
Figure 1
Designing smart agents through the combination of H2S pharmacological properties with old drugs.
See this image and copyright information in PMC

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