Review
doi: 10.1016/s0140-6736(88)90753-2.
Genetics of classic Alport's syndrome
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- PMID: 2902439
- DOI: 10.1016/s0140-6736(88)90753-2
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Review
Genetics of classic Alport's syndrome
Lancet.
.
Abstract
41 families with classic Alport's syndrome (hereditary nephritis with sensorineural deafness) were studied. All their pedigrees were compatible with X-linked inheritance. DNA probes were used to investigate genetic linkage in these families. Linkage to probe S21 (DXS17) was confirmed (LOD score = 4.72 at 0 = 0.06), localising the gene for Alport's syndrome to the middle of Xq; thus the disorder is X-chromosomal in nature.
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