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Review
. 1988 Oct 29;2(8618):1005-7.
doi: 10.1016/s0140-6736(88)90753-2.

Genetics of classic Alport's syndrome

F A Flinter  1 , J S Cameron, C Chantler, I Houston, M Bobrow
Affiliations
Review

Genetics of classic Alport's syndrome

F A Flinter et al. Lancet. .

Abstract

41 families with classic Alport's syndrome (hereditary nephritis with sensorineural deafness) were studied. All their pedigrees were compatible with X-linked inheritance. DNA probes were used to investigate genetic linkage in these families. Linkage to probe S21 (DXS17) was confirmed (LOD score = 4.72 at 0 = 0.06), localising the gene for Alport's syndrome to the middle of Xq; thus the disorder is X-chromosomal in nature.

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