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Comment
. 2017 Oct 11;22(4):432-433.
doi: 10.1016/j.chom.2017.09.013.

Shigella Stays on the Move

Noelia Lopez-Montero  1 , Jost Enninga  2
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Shigella Stays on the Move

Noelia Lopez-Montero et al. Cell Host Microbe. .
Free article

Abstract

Guanylate-binding proteins (GBPs) confer protection against intracellular pathogens. In this issue of Cell Host & Microbe, Wandel et al. (2017) report that cytosolic Shigella becomes trapped within a GBP coat that prevents bacterial cell-to-cell spread. However, this defense mechanism is counteracted by the bacterial E3 ubiquitin ligase IpaH9.8.

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