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. 1988 Oct;85(20):7675-9.
doi: 10.1073/pnas.85.20.7675.

Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

N Sacchi  1 , J Nalbantoglu, F R Sergovich, T S Papas
Affiliations

Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

N Sacchi et al. Proc Natl Acad Sci U S A. 1988 Oct.

Abstract

The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected in DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.

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References

    1. Dev Biol. 1984 Feb;101(2):416-24 - PubMed
    1. J Pediatr. 1964 Aug;65:197-207 - PubMed
    1. Ann N Y Acad Sci. 1985;450:157-68 - PubMed
    1. Ann N Y Acad Sci. 1985;450:223-38 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7294-8 - PubMed