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Review
. 2017 Aug 31:6:1615.
doi: 10.12688/f1000research.11351.1. eCollection 2017.

Recent advances in cerebral oximetry. Assessment of cerebral autoregulation with near-infrared spectroscopy: myth or reality?

Anneliese Moerman  1 , Stefan De Hert  1
Affiliations
Review

Recent advances in cerebral oximetry. Assessment of cerebral autoregulation with near-infrared spectroscopy: myth or reality?

Anneliese Moerman et al. F1000Res. .

Abstract

In recent years, the feasibility of near-infrared spectroscopy to continuously assess cerebral autoregulation has gained increasing interest. By plotting cerebral oxygen saturation over blood pressure, clinicians can generate an index of autoregulation: the cerebral oximetry index (COx). Successful integration of this monitoring ability in daily critical care may allow clinicians to tailor blood pressure management to the individual patient's need and might prove to be a major step forward in terms of patient outcome.

Keywords: Cerebral autoregulation; NIRS; Oximetry.

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Conflict of interest statement

Competing interests: AM has received lecture fees from Medtronic (INVOS) and Sorin (NIRO). SD declares that he has no competing interests.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Classic depiction of cerebral autoregulation, with autoregulation plateau, lower limit of autoregulation (LLA), and upper limit of autoregulation (ULA).
CBF, cerebral blood flow; MAP, mean arterial blood pressure.
Figure 2.
Figure 2.. Correlation of changes in mean arterial pressure (MAP) with changes in cerebral oxygen saturation (S cO 2) with administration of three different vasodilating drugs.
The drugs are sevoflurane (Sevo), sodium nitroprusside (SNP), and nitroglycerin (NTG). Own data, not published.
Figure 3.
Figure 3.. The autoregulation curve may vary from the classic depiction of autoregulation, with unknown limits of autoregulation (question marks), and an optimal mean arterial blood pressure (square).
CBF, cerebral blood flow; MAP, mean arterial blood pressure.
Figure 4.
Figure 4.. Near-infrared spectroscopy (NIRS)-derived oxygen saturation versus cerebral perfusion pressure (CPP), depicting the cerebral autoregulation curve.
The correlations generate the cerebral oximetry index (COx). Adapted from Brady et al. .
See this image and copyright information in PMC

References

    1. Green DW, Kunst G: Cerebral oximetry and its role in adult cardiac, non-cardiac surgery and resuscitation from cardiac arrest. Anaesthesia. 2017;72 Suppl 1:48–57. 10.1111/anae.13740 - DOI - PubMed

    2. F1000 Recommendation

    1. Bickler P, Feiner J, Rollins M, et al. : Tissue Oximetry and Clinical Outcomes. Anesth Analg. 2017;124(1):72–82. 10.1213/ANE.0000000000001348 - DOI - PubMed

    2. F1000 Recommendation

    1. Moerman A, De Hert S: Cerebral oximetry: the standard monitor of the future? Curr Opin Anaesthesiol. 2015;28(6):703–9. 10.1097/ACO.0000000000000256 - DOI - PubMed
    1. Lassen NA: Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959;39(2):183–238. - PubMed
    1. Drummond JC: The lower limit of autoregulation: time to revise our thinking? Anesthesiology. 1997;86(6):1431–3. - PubMed

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