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Review
. 2017 Sep-Oct;7(5):227-233.
doi: 10.4103/jispcd.JISPCD_429_16. Epub 2017 Sep 18.

Platelet-rich Fibrin: A Paradigm in Periodontal Therapy - A Systematic Review

Umesh Pratap Verma  1 , Rakesh Kumar Yadav  2 , Manisha Dixit  1 , Abhaya Gupta  1
Affiliations
Review

Platelet-rich Fibrin: A Paradigm in Periodontal Therapy - A Systematic Review

Umesh Pratap Verma et al. J Int Soc Prev Community Dent. 2017 Sep-Oct.

Abstract

Periodontal tissue regeneration has always been a challenge for the periodontists owing to its structural complexity. Although with tissue engineering as a growing multidisciplinary field, this aim has partially been fulfilled. In recent years, platelet-rich fibrin (PRF) has gained wide attention for its utilization as a biocompatible regenerative material not only in dental but also in medical fields. The following systematic review has gathered all the currently available in vitro, animal, and clinical studies utilizing PubMed electronic database from January 2006 to August 2016 highlighting PRF for soft and hard tissue regeneration and/or wound healing. Although results are encouraging but require further validation from clinical studies to justify the potential role of PRF in periodontal regeneration so that this relatively inexpensive autologous biomaterial can be utilized at a wider scale.

Keywords: Intrabony defect; platelet concentrates; platelet-rich fibrin; regeneration; wound healing.

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Figures

Figure 1
Figure 1
Description of different types of platelet rich concentrates
Figure 2
Figure 2
Role of platelet-rich fibrin growth factors and cytokines in tissue regeneration and wound healing. Transforming growth factor ß1, insulin-like growth factor 1 and 2, platelet-derived growth factor, cytokine vascular endothelial growth factor, and interleukin 1, 4, and 6
See this image and copyright information in PMC

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