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. 2017 Jan-Mar;6(1):63-68.
doi: 10.4103/2249-4863.214958.

Association of thyroid peroxidase antibody and dyslipidemia in subclinical hypothyroidism

Vikas Kumar Srivastava  1 , Harkaran Singh  1
Affiliations

Association of thyroid peroxidase antibody and dyslipidemia in subclinical hypothyroidism

Vikas Kumar Srivastava et al. J Family Med Prim Care. 2017 Jan-Mar.

Abstract

Context: Subclinical hypothyroidism (SCH) is stated as mild thyroid failure, is more common as compared to overt hypothyroidism, is associated with different biochemical abnormalities such as dyslipidemia, and is also having high conversion rate into overt hypothyroidism in patients having thyroid peroxidase (TPO) antibody positive. Lipid abnormalities are controversial in SCH and there is lack of Indian studies showing correlation between lipid abnormalities and TPO positivity in SCH. Hence, we did this study to find the TPO positivity and associated dyslipidemia in SCH patients.

Materials and methods: It was a prospective observational study from January 2015 to December 2015 including fifty adult diagnosed SCH patients presented in outpatient department of Sri Balaji Action Medical Institute, Paschim Vihar, New Delhi. TPO positivity and different lipid abnormalities were studied in those fifty diagnosed SCH patients, and finally, association between TPO antibody and dyslipidemia was calculated.

Results: Females were predominant (86%). TPO was positive in 56% SCH patients. Dyslipidemia was found in 100% of SCH patients with positive TPO antibody. In overall, TPO positive patients as well as TPO positive females, total cholesterol, triglyceride, and low-density lipoprotein were significantly high while high-density lipoprotein was insignificant. In males, no significant association was found.

Conclusion: In SCH patients, dyslipidemia is significantly associated with TPO positivity, especially in females. Hence, early screening, diagnosis, and treatment of SCH patients are recommended to prevent further risks.

Keywords: Dyslipidemia; lipid profile; subclinical hypothyroidism; thyroid; thyroid peroxidase.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Correlation between abnormal lipid and thyroid peroxidase
Figure 2
Figure 2
Correlation between total cholesterol and thyroid peroxidase in male
Figure 3
Figure 3
Correlation between total cholesterol and thyroid peroxidase in female
Figure 4
Figure 4
Correlation between high-density lipoprotein and thyroid peroxidase in male
Figure 5
Figure 5
Correlation between high-density lipoprotein and thyroid peroxidase in female
Figure 6
Figure 6
Correlation between low-density lipoprotein and thyroid peroxidase in male
Figure 7
Figure 7
Correlation between low-density lipoprotein and thyroid peroxidase in female
Figure 8
Figure 8
Correlation between triglyceride and thyroid peroxidase in male
Figure 9
Figure 9
Correlation between triglyceride and thyroid peroxidase in female
See this image and copyright information in PMC

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