Recombinations between IRP and cystic fibrosis
- PMID: 2902786
- PMCID: PMC1715502
Recombinations between IRP and cystic fibrosis
Abstract
A candidate gene for cystic fibrosis was recently isolated by selective cloning of HpaII-tiny-fragment islands; it maps considerably closer to CF than does MET or D7S8 (pJ3.11), and DNA polymorphisms from this region are in marked disequilibrium with CF. cDNA cloning has shown that this protein has a growth factor-like structure and shows homology to the murine and human proto-oncogene int-1; it is designated IRP (int-1-related protein). DNA sequences from the IRP locus that recognize RFLPs are proving to be highly informative for prenatal diagnosis. We report five crossovers that have been identified which occur either within the IRP locus or between IRP and CF; these recombinants demonstrate that CF maps between the DNA markers D7S8 and KM.19.
Comment in
-
Analysis of delta F508 does not confirm a previously reported recombination in a cystic fibrosis family.Am J Hum Genet. 1990 May;46(5):1004-5. Am J Hum Genet. 1990. PMID: 1971140 Free PMC article. No abstract available.
Similar articles
-
Isolation of a new DNA marker in linkage disequilibrium with cystic fibrosis, situated between J3.11 (D7S8) and IRP.Am J Hum Genet. 1989 May;44(5):704-10. Am J Hum Genet. 1989. PMID: 2565082 Free PMC article.
-
Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.Am J Hum Genet. 1986 Dec;39(6):681-93. Am J Hum Genet. 1986. PMID: 3026171 Free PMC article.
-
Isolation of additional polymorphic clones from the cystic fibrosis region, using chromosome jumping from D7S8.Am J Hum Genet. 1989 May;44(5):695-703. Am J Hum Genet. 1989. PMID: 2565081 Free PMC article.
-
Progress towards cloning the cystic fibrosis gene.Philos Trans R Soc Lond B Biol Sci. 1988 Jun 15;319(1194):263-73. doi: 10.1098/rstb.1988.0048. Philos Trans R Soc Lond B Biol Sci. 1988. PMID: 2900520 Review.
-
The application of molecular genetics to the study of the basic defect causing cystic fibrosis.Prog Clin Biol Res. 1987;254:181-90. Prog Clin Biol Res. 1987. PMID: 2893385 Review.
Cited by
-
Frequency of the F508 deletion in cystic fibrosis patients from the European part of the USSR.Hum Genet. 1991 May;87(1):61-4. doi: 10.1007/BF01213094. Hum Genet. 1991. PMID: 2037283
-
Cystic fibrosis mutations in the Hutterite Brethren.Am J Hum Genet. 1990 May;46(5):983-7. Am J Hum Genet. 1990. PMID: 2339696 Free PMC article.
-
Tracing the mutations in cystic fibrosis by means of closely linked DNA markers.Am J Hum Genet. 1989 Mar;44(3):303-6. Am J Hum Genet. 1989. PMID: 2916577 Free PMC article. No abstract available.
-
The cystic fibrosis defect approached from different angles--new perspectives on the gene, the chloride channel, diagnosis and therapy.Eur J Pediatr. 1990 Jul;149(10):670-7. doi: 10.1007/BF01959519. Eur J Pediatr. 1990. PMID: 1698628 Review.
-
Linkage disequilibrium, cystic fibrosis, and genetic counseling.Am J Hum Genet. 1989 Mar;44(3):319-26. Am J Hum Genet. 1989. PMID: 2916578 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous