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Comment
. 2017 Dec;13(12):697-698.
doi: 10.1038/nrendo.2017.136. Epub 2017 Oct 13.

Bone diseases: Romosozumab - on track or derailed?

Sundeep Khosla  1
Affiliations
Comment

Bone diseases: Romosozumab - on track or derailed?

Sundeep Khosla. Nat Rev Endocrinol. 2017 Dec.

Abstract

Romosozumab, a recently developed sclerostin inhibitor, stimulates bone formation and inhibits bone resorption, thereby markedly increasing bone mass and reducing fracture risk. But will a red flag regarding possible adverse cardiovascular events derail this promising new drug for osteoporosis?

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Conflict of interest statement

Competing interests statement

The author declares no competing interests.

Comment on

References

    1. Khosla S & Hofbauer LC Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 10.1016/s2213-8587(17)30188-2 (2017). - DOI - PMC - PubMed
    1. Brunkow ME et al. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot‑containing protein. Am. J. Hum. Genet 68, 577–589 (2001). - PMC - PubMed
    1. Khosla S, Westendorf JJ & Oursler MJ Building bone to reverse osteoporosis and repair fractures. J. Clin. Invest 118, 421–428 (2008). - PMC - PubMed
    1. Li X et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J. Bone Miner. Res 24, 578–588 (2009). - PubMed
    1. McClung MR et al. Romosozumab in postmenopausal women with low bone mineral density. N. Engl. J. Med 370, 412–420 (2014). - PubMed

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