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. 2018 Mar;14(3):271-279.
doi: 10.1016/j.jalz.2017.08.015. Epub 2017 Oct 10.

Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study

Isaac Acosta  1 , Guilherme Borges  2 , Rebeca Aguirre-Hernandez  3 , Ana Luisa Sosa  4 , Martin Prince  5 ; 10/66 Dementia Research Group
Affiliations

Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group study

Isaac Acosta et al. Alzheimers Dement. 2018 Mar.

Abstract

Introduction: Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence.

Methods: We analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow-up, modeling cumulative incidence ratios using Poisson models.

Results: Five neuropsychiatric symptoms were associated with incident dementia: delusions, hallucinations, anxiety, aberrant motor behavior, and depression. The simultaneous presence of two symptoms had a relative risk, adjusted for mild cognitive impairment, diabetes, indicators of cognitive function, and sociodemographic factors, of 1.9 (95% confidence interval, 1.2-2.9), whereas the presence of three to five, similarly adjusted, had a relative risk of 3.0 (95% confidence interval, 1.9-4.8).

Discussion: Neuropsychiatric symptoms are common in predementia states and may independently contribute as risk factors for developing dementia.

Keywords: Aged; Dementia; Neuropsychiatric symptoms; Population-based study; Risk factors.

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Figures

Fig. 1
Fig. 1
ROC curves for full index (range 0–6), reduced index without MCI (range 0–5), and reduced index without NPS (range 0–5). Abbreviations: AUC, total area under the receiver operating characteristic curve; MCI, mild cognitive impairment; NPS, neuropsychiatric symptom; PNV, predictive negative value; PPV, predictive positive value.
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