Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov 13;31(17):2431-2433.
doi: 10.1097/QAD.0000000000001661.

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha  1 , Joana Duarte, Pedro Borrego, Rita Calado, José Maria Marcelino, Rita Tendeiro, Emília Valadas, Ana Espada Sousa, Nuno Taveira
Affiliations

Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells

Cheila Rocha et al. AIDS. .

Abstract

: Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.

PubMed Disclaimer

Publication types