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Review
. 2017 Oct;38(Suppl 2):217-224.
doi: 10.1007/s10072-017-3034-2.

Cerebrospinal fluid analysis and the determination of oligoclonal bands

Matteo Gastaldi  1 , Elisabetta Zardini  1 , Rosaria Leante  2 , Maddalena Ruggieri  2 , Gianna Costa  3 , Eleonora Cocco  3 , Giovanna De Luca  4 , Ivana Cataldo  4 , Tiziana Biagioli  5 , Clara Ballerini  6 , Massimiliano Castellazzi  7 , Enrico Fainardi  6 , Paola Pettini  8 , Mauro Zaffaroni  8 , Debora Giunti  9 , Elisabetta Capello  9 , Gaetano Bernardi  10 , Emilio Ciusani  10 , Claudia Giannotta  11 , Eduardo Nobile-Orazio  11 , Elena Bazzigaluppi  12 , Gabriella Passerini  12 , Roberta Bedin  13 , Patrizia Sola  13 , Rinaldo Brivio  14 , Guido Cavaletti  15 , Arianna Sala  16 , Antonio Bertolotto  16 , Gaetano Desina  17 , Maurizio A Leone  17 , Sara Mariotto  18 , Sergio Ferrari  18 , Andreina Paternoster  19 , Davide Giavarina  19 , Francesco Lolli  6 , Diego Franciotta  20
Affiliations
Review

Cerebrospinal fluid analysis and the determination of oligoclonal bands

Matteo Gastaldi et al. Neurol Sci. 2017 Oct.

Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Keywords: Intrathecal IgG synthesis; Isoelectric focusing; Laboratory diagnostics; Multiple sclerosis; Neuroimmunology.

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