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Review
. 2017 Nov:126:98-104.
doi: 10.1016/j.plefa.2017.09.017. Epub 2017 Sep 23.

The role of specialized pro-resolving mediators in maternal-fetal health

E Elliott  1 , C K Hanson  2 , A L Anderson-Berry  1 , T M Nordgren  3
Affiliations
Review

The role of specialized pro-resolving mediators in maternal-fetal health

E Elliott et al. Prostaglandins Leukot Essent Fatty Acids. 2017 Nov.

Abstract

Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

Keywords: Docosahexaenoic acid; Fetal health; Omega-3 fatty acid; Pregnancy; Pro-resolving lipid mediator; Resolvins.

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Figures

<sup>3</sup>Figure 1
3Figure 1
[11,13,25,33] (a) Pathway for the production of lipoxins from omega-6 fatty acids (b) Pathway for the production of resolvins, maresins, and protectins from omega-3 fatty acids 3Figure 1 Abbreviations AA: Arachidonic acid 15-HETE: 15-hydroxyeicosatetraenoic acid EPA: Eicosapentaenoic acid DHA: Docosahexaenoic acid 18-HEPE: 18-hydroxyeicosapentaenoic acid 17-H(p)DHA: 17-hydroperoxydocosahexaenoic acid 17-HDHA: 17-hydroperoxydocosahexanoic acid 14-HDHA: 14-hydroperoxydocosahexaenoic acid 4-HDHA: 4-hydroxydocosahexaenoic acid 5-LO: 5-lipoxygenase 12/15-LO: 12/15-lipoxygenases P450: cytochrome P450 COX2: cyclooxygenase-2
See this image and copyright information in PMC

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