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. 2017 Oct:38:50-57.
doi: 10.1016/j.sleep.2017.06.035. Epub 2017 Jul 26.

Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort

Ghada Bourjeily  1 , Valery A Danilack  2 , Margaret H Bublitz  3 , Heather Lipkind  4 , Janet Muri  5 , Donna Caldwell  5 , Iris Tong  6 , Karen Rosene-Montella  7
Affiliations

Obstructive sleep apnea in pregnancy is associated with adverse maternal outcomes: a national cohort

Ghada Bourjeily et al. Sleep Med. 2017 Oct.

Abstract

Objective: Pregnancy and the obesity epidemic impacting women of reproductive age appear to predispose women to obstructive sleep apnea (OSA) in pregnancy. The aim of this study is to examine the association between OSA and adverse maternal outcomes in a national cohort.

Methods: The National Perinatal Information Center in the US was used to identify women with a delivery discharge diagnosis of OSA from 2010 to 2014. We used the International Classification of Diseases, ninth Revision to classify OSA diagnosis and maternal outcomes.

Measurements: The sample consisted of 1,577,632 gravidas with a rate of OSA of 0.12% (N = 1963). There was a significant association between OSA and preeclampsia (adjusted odds ratio (aOR) 2.22, 95% confidence interval (CI) 1.94-2.54), eclampsia (aOR 2.95, 1.08-8.02), and gestational diabetes (aOR 1.51, 1.34-1.72) after adjusting for a comprehensive list of covariates which includes maternal obesity. OSA status was also associated with a 2.5-3.5-fold increase in risk of severe complications such as cardiomyopathy, congestive heart failure, and hysterectomy. Length of hospital stay was significantly longer (5.1 + 5.6 vs 3.0 + 3.0 days, p < 0.001) and odds of an admission to an intensive care unit higher (aOR 2.74, 2.36-3.18) in women with OSA.

Conclusions: Compared to pregnant women without OSA, pregnant women with OSA have a significantly higher risk of pregnancy-specific complications such as gestational hypertensive conditions and gestational diabetes, and rare medical and surgical complications such as cardiomyopathy, pulmonary edema, congestive heart failure, and hysterectomy. OSA diagnosis was also associated with a longer hospital stay and significantly increased odds for admission to the intensive care unit.

Keywords: Gestational diabetes; Gestational hypertensive disorders; ICU stay; Obstructive sleep apnea; Pregnancy; Severe maternal morbidity.

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Conflict of interest statement

Conflict of interest

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Obstructive sleep apnea status and prevalence of pregnancy-specific complications p<0.001 for all outcomes. IUGR: Intrauterine growth restriction; OSA: Obstructive sleep apnea
Figure 2
Figure 2
Risk of maternal and surgical complications by OSA status. Odds ratios in this figure have been adjusted using model 3. ICU: intensive care unit.
See this image and copyright information in PMC

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