Molecular mechanisms of nickel induced neurotoxicity and chemoprevention

Abstract

Nickel (Ni) is widely used in many industrial sectors such as alloy, welding, printing inks, electrical and electronics industries. Excessive environmental or occupational exposure to Ni may result in tumor, contact dermatitis, as well as damages to the nervous system. In recent years, more and more research has demonstrated that Ni induced nerve damages are related to mitochondrial dysfunction. In this paper, we try to characterize Ni induced neurotoxicity as well as the underlying mechanisms, and how to find new drugs for chemoprevention, by reviewing chemicals with neuroprotective effects on Ni induced neurotoxicity.

Keywords: Antioxidants; Chemoprevention; Mitochondria dysfunction; Neuroprotective effect; Neurotoxicity; Nickel.