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Review
. 2018 Jan;410(3):695-713.
doi: 10.1007/s00216-017-0632-z. Epub 2017 Oct 14.

Advances in microRNA analysis

Despina P Kalogianni  1 , Panagiota M Kalligosfyri  1 , Iraklis K Kyriakou  1 , Theodore K Christopoulos  2   3
Affiliations
Review

Advances in microRNA analysis

Despina P Kalogianni et al. Anal Bioanal Chem. 2018 Jan.

Abstract

MicroRNAs (miRNAs) are single-stranded noncoding RNA molecules that act as key regulators of mRNA expression and are emerging biomarkers for disease. Their small size (18-25 nt) presents challenges to molecular recognition, labeling, and signal generation. Recent research activity in this field has aimed at the development of methods for miRNA quantification that combine high detectability, broad dynamic range, practicality, multiplexity, and low cost for prospective applications in diagnostic laboratories. This review article covers the most recent advances in microRNA analysis.

Keywords: Amplification; Biosensors; Hybridization chain reaction; MicroRNA; Nanoparticles; Target recycling.

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