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. 2018 Sep;81(9):825-829.
doi: 10.1016/j.jcma.2017.08.013. Epub 2017 Oct 9.

Soluble urokinase-type plasminogen activator receptor (suPAR) and interleukin-6 levels in hyperemesis gravidarum

Raziye Desdicioglu  1 , Melahat Yildirim  2 , Gulcan Kocaoglu  3 , Busra Demir Cendek  4 , Gamze Avcioglu  5 , Emre Erdem Tas  2 , Ozlem Sengul  2 , Ozcan Erel  5 , Ayse Filiz Yavuz  2
Affiliations
Free article

Soluble urokinase-type plasminogen activator receptor (suPAR) and interleukin-6 levels in hyperemesis gravidarum

Raziye Desdicioglu et al. J Chin Med Assoc. 2018 Sep.
Free article

Abstract

Background: The aim was to compare serum soluble urokinase-type plasminogen activator receptor (suPAR) levels as well as interleukin-6 levels (IL-6) in pregnant women with hyperemesis gravidarum (HG) and asymptomatic pregnant women.

Methods: Our study population consists of voluntary first trimester-pregnant women who applied to the outpatient clinic of the department of obstetrics and gynecology of Ankara Ataturk Training and Research Hospital. Between February and May 2016, 60 pregnant women were included in our prospective study. Serum suPAR and IL-6 levels were evaluated with the ELISA method. Twenty-nine pregnant women with HG and 31 asymptomatic pregnant women were included in the study.

Results: Serum suPAR level in the HG group was measured as 0.36 ± 0.56 ng/ml, whereas this level in the healthy pregnant control group was measured as 0.15 ± 0.15 ng/ml (p < 0.05). The interleukin-6 level in the HG group was 5.69 ± 2.16 pg/ml, whereas in the control group it was measured as 3.88 ± 0.28 pg/ml (p < 0.05).

Conclusion: Serum suPAR and IL-6 levels proved to be high in the HG group. It is likely that suPAR could play a role in the etiopathogenesis of hyperemesis gravidarum.

Keywords: Hyperemesis gravidarum; Interleukin-6; Soluble urokinase-type plasminogen activator receptor; suPAR.

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Comment in

  • Hyperemesis gravidarum.
    Yeh CC, Tsui KH, Wang PH. Yeh CC, et al. J Chin Med Assoc. 2018 Sep;81(9):755-756. doi: 10.1016/j.jcma.2017.09.001. Epub 2017 Sep 29. J Chin Med Assoc. 2018. PMID: 28969993 No abstract available.