The evaluation and management of respiratory disease in children with Down syndrome (DS)

Abstract

Children with Down syndrome (DS) have wide range of respiratory problems. Although underlying abnormalities in the respiratory system are important causes of morbidity and mortality in children with DS, particularly in the young, abnormalities in other organ systems may also impact respiratory function. A comprehensive evaluation of the child with DS and respiratory disease may prevent short-term morbidity and mortality, and reduce the incidence of complications in the long term. This review provides an overview of the various causes of respiratory disease, and insight into some of the newer therapies available to treat obstructive sleep apnea, in this population.

Keywords: Adenotonsillectomy; Congenital Heart Disease; Gastroesophageal reflux; Polysomnography; Recurrent wheeze; Upper airway obstruction.