Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep 29:7:236.
doi: 10.3389/fonc.2017.00236. eCollection 2017.

The Role of ATRX in Glioma Biology

Pravanya Nandakumar  1 , Alireza Mansouri  2   3 , Sunit Das  1   4
Affiliations
Review

The Role of ATRX in Glioma Biology

Pravanya Nandakumar et al. Front Oncol. .

Abstract

The current World Health Organization classification of CNS tumors has made a tremendous leap from past editions by incorporating molecular criteria in addition to the pre-existing histological parameters. The revised version has had a particular impact on the classification of diffuse low-grade gliomas and their high-grade variants. The ATRX status is one of the critical markers that define the molecular classification of gliomas. In this review, we will first provide an overview of the role of ATRX in regular cell biology. Furthermore, the role of ATRX in tumorigenesis, specifically gliomas, is comprehensively elucidated. The possible correlation of ATRX status with other genetic/epigenetic modifications is also presented. We conclude by discussing some of the challenges associated with incorporating ATRX status assessment into routine clinical practice while also exploring opportunities for future diagnostics/therapeutics in gliomas based on ATRX status.

Keywords: ATRX; IDH; astrocytoma; glioma; oligodendroglioma.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schema of molecular alterations in various grades of gliomas.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol (2016) 131:803–20.10.1007/s00401-016-1545-1 - DOI - PubMed
    1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumors of the central nervous system. Acta Neuropathol (2007) 114(2):97–109.10.1007/s00401-007-0243-4 - DOI - PMC - PubMed
    1. Mennel HD. Grading of intracranial tumors following the WHO classification. Neurosurg Rev (1991) 14(4):249–60.10.1007/BF00383256 - DOI - PubMed
    1. Kleihues P, Burger PC, Scheithauer BW. The new WHO classification of brain tumors. Brain Pathol (1993) 3(3):255–68.10.1111/j.1750-3639.1993.tb00752.x - DOI - PubMed
    1. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol (2002) 61(3):215–25.10.1093/jnen/61.3.215 - DOI - PubMed