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Review
. 2018 Jan;472(1):29-41.
doi: 10.1007/s00428-017-2238-4. Epub 2017 Oct 15.

Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges

Melanie E Johncilla  1 , Amitabh Srivastava  2
Affiliations
Review

Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges

Melanie E Johncilla et al. Virchows Arch. 2018 Jan.

Abstract

There has been much progress in our understanding of esophageal inflammatory disorders in the past few years. This is particularly true about esophageal eosinophilia and PPI responsiveness, lymphocytic esophagitis and motility disorders, and short-term risk of neoplasia in esophageal leukoplakia. The current review will summarize esophageal injury patterns that primarily occur due to non-reflux causes, with a focus on usual pitfalls in biopsy diagnosis and recent advances in our knowledge of the more common forms of esophagitis.

Keywords: Eosinophilic esophagitis; Esophagus; Histopathology; Inflammation; Leukoplakia; Lymphocytic esophagitis.

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