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. 2017 Oct 21;43(6):1158-1163.
doi: 10.1093/schbul/sbx094.

Barbara Fish and a Short History of the Neurodevelopmental Hypothesis of Schizophrenia

Assen Jablensky  1 , Thomas F McNeil  2   3 , Vera A Morgan  1   3
Affiliations

Barbara Fish and a Short History of the Neurodevelopmental Hypothesis of Schizophrenia

Assen Jablensky et al. Schizophr Bull. .

Abstract

The neurodevelopmental hypothesis of schizophrenia has become a paradigm broadly accepted in today's research in schizophrenia and its spectrum. This article traces the historical development of the neurodevelopmental hypothesis of schizophrenia up until the time of its explicit formulation in 1987, by Weinberger and by Murray and Lewis, with a main focus on the seminal contribution of Barbara Fish to its conception and elaboration.

Keywords: environmental risk; genetic risk; high risk studies; neurodevelopment; obstetric complications; pandysmaturation; schizophrenia.

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References

    1. Weinberger DR. The pathogenesis of schizophrenia: a neurodevelopmental theory. In: Nasrallah HA, Weinberger DR, eds. The Neurology of Schizophrenia. Amsterdam: Elsevier; 1986:397–406.
    1. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry. 1987;44:660–669. - PubMed
    1. Murray RM, Lewis SW. Is schizophrenia a neurodevelopmental disorder? Br Med J (Clin Res Ed). 1987;295:681–682. - PMC - PubMed
    1. Lewis SW, Murray RM. Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. J Psychiatr Res. 1987;21:413–421. - PubMed
    1. Fish B. The detection of schizophrenia in infancy; a preliminary report. J Nerv Ment Dis. 1957;125:1–24. - PubMed

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