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. 2017 Sep 30;21(3):55-61.
doi: 10.20463/jenb.2017.0027.

The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise

Chan-Sik Kim  1 , Sok Park  2 , Junghyun Kim  3
Affiliations

The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise

Chan-Sik Kim et al. J Exerc Nutrition Biochem. .

Abstract

Purpose: Advanced glycation end products (AGEs) are non-enzymatic modifications of proteins or lipids after exposure to sugars. In this review, the glycation process and AGEs are introduced, and the harmful effects of AGEs in the aging process are discussed.

Methods: Results from human and animal studies examining the mechanisms and effects of AGEs are considered. In addition, publications addressing means to attenuate glycation stress through AGE inhibitors or physical exercise are reviewed.

Results: AGEs form in hyperglycemic conditions and/or the natural process of aging. Numerous publications have demonstrated acceleration of the aging process by AGEs. Exogenous AGEs in dietary foods also trigger organ dysfunction and tissue aging. Various herbal supplements or regular physical exercise have beneficial effects on glycemic control and oxidative stress with a consequent reduction of AGE accumulation during aging.

Conclusion: The inhibition of AGE formation and accumulation in tissues can lead to an increase in lifespan.

Keywords: Advanced glycation end products; Aging; Glycation; Herbal products; Physical exercise.

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Figures

Figure 1.
Figure 1.. Glycation process leading to the formation of advanced glycation end-products (AGEs). Illustration from Bohlender et al., 2005.
Figure 2.
Figure 2.. Examples of biologically relevant advanced glycation end-products (AGEs). Illustration from Sadowska-Bartoz and Bartosz, 2016.
See this image and copyright information in PMC

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