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Case Reports
. 2017 Dec;35(12):1984.e1-1984.e2.
doi: 10.1016/j.ajem.2017.07.084. Epub 2017 Aug 18.

Pulmonary embolism due to exogenous estrogen intoxication

Caner Çelik  1 , Murat Carus  2 , Fatih Büyükcam  3
Affiliations
Case Reports

Pulmonary embolism due to exogenous estrogen intoxication

Caner Çelik et al. Am J Emerg Med. 2017 Dec.

Abstract

Objective: Pulmonary embolism is a relatively common clinical presentation of venous thromboembolism, which develops in relation to acute pulmonary arterial occlusion mostly caused by thrombi of the lower limbs.

Case report: 29year old female admitted to emergency department with pulmonary thromboembolism due to an ingestion of 17 Diana 35 pills (2 mg cyproterone acetate and 0.035mg ethinyl estradiol) in a suicide attempt without any previously known predisposing factors. After thrombolytic therapy, the patient was discharged with oral warfarin treatment.

Discussion: We know that exogenous estrogen increase the risk of venous thromboembolism in therapeutic use. It should be kept in mind that even single ingestion of a single high-dose exogenous estrogen intake may induce pulmonary thromboembolism.

Keywords: Drug overdose; Ethinyl estradiol; Oral contraceptives; Pulmonary embolism; Venous thromboembolism.

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