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. 2017 Dec;16(4):431-437.
doi: 10.1007/s12663-016-0946-y. Epub 2016 Jul 29.

Mucoepidermoid Carcinoma of the Salivary Glands: Survival and Prognostic Factors

Guevara-Canales Janet-Ofelia  1 , Morales-Vadillo Rafael  1 , Guzmán-Arias Guillermo  1 , Cava-Vergiú Carlos-Enrique  1 , Robello-Malatto José-Martín  1 , Guerra-Miller Henry  2 , Montes-Gil Jaime-Enrique  2
Affiliations

Mucoepidermoid Carcinoma of the Salivary Glands: Survival and Prognostic Factors

Guevara-Canales Janet-Ofelia et al. J Maxillofac Oral Surg. 2017 Dec.

Abstract

Objective: The aim of this study was to establish global survival rates and potential prognostic factors for mucoepidermoid carcinoma (MC) of the salivary glands in patients diagnosed at the Dr. Eduardo Cáceres Graziani National Institute for Neoplastic Diseases (INEN), Lima, Peru, between 2002 and 2012.

Materials and methods: This was an observational, analytical and longitudinal (information reconstructed in time) retrospective cohort study. Data were obtained from clinical records and used to determine the overall survival (OS) rate at 2 and 5 years, and the individual percentage survival for each prognostic factor using the actuarial technique. We also performed univariate analysis for each possible prognostic factor using log-rank analysis, and multivariate analysis using Cox's regression model. The study was approved by the institutional review board at Dr. Eduardo Caceres Graziani INEN and conducted in accordance with the 1964 Declaration of Helsinki. For this type of study formal consent was not required.

Results: The OS rate of the 51 patients enrolled in the study was 81 % at 2 years and 78 % at 5 years. In the multivariate analysis, the equation that best explained the survival result contained the variable, clinical stage (p = 0.063).

Conclusions: The results revealed the importance of clinical stage regarding the survival of patients with a primary diagnosis of MC of the salivary glands.

Keywords: Mucoepidermoid carcinoma; Neoplasms; Salivary gland; Survival.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no competing interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at Dr. Eduardo Caceres Graziani INEN (protocol: INEN 13:27) and conducted in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

For this type of study formal consent is not required to be retrospective.

Figures

Fig. 1
Fig. 1
Overall survival curve for patients with MC of the salivary glands seen at the Dr. Eduardo Caceres Graziani INEN, Lima, Peru, from 2002 to December 2012
Fig. 2
Fig. 2
Mortality and Kaplan–Meier curves with multivariate significance determined by the log-rank test, clinical stage predictor, for subjects with MC of the salivary glands seen at the Dr. Eduardo Caceres Graziani INEN, Lima, Peru, from January 2002 to December 2012
See this image and copyright information in PMC

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